This book provides a measured collation of the state of the art of emerging techniques to design and development of flexible robotic microgrippers driven by piezoelectric actuators. It aims to cover mechanical designs of microgrippers with both simulation and experimental verifications. This book contains theoretical modeling, prototype fabrication, and extensive experimental investigations of piezo-driven microgrippers. It also incorporates the most emerging precision motion control techniques using reinforcement learning-based adaptive control. This book demonstrates combined mechanical design and motion control design of piezoelectric microgripper devices dedicated to micromanipulation application. This book is intended for undergraduate and graduate students who are interested in flexure-based compliant mechanisms, researchers investigating piezoelectric-actuated devices, and structure/control design engineers working on ultrahigh precision motion devices for micromanipulation applications.