Khronicheskie diffuznye zabolevaniya pecheni, svyazannye s gepatotropnymi virusami, yavlyayutsya vazhneyshey problemoy zdravookhraneniya v svyazi s ikh shirokoy rasprostranennost'yu, neuklonnym rostom zabolevaemosti, invalidizatsii i smertnosti. V patogeneze khronicheskikh virusnykh gepatitov i progressirovanii ikh v tsirroz pecheni, pomimo pryamogo tsitopaticheskogo deystviya virusa s vklyucheniem immunooposredovannykh mekhanizmov, bol'shoe znachenie imeet narushenie vnutripechenochnoy gemodinamiki, chto svyazano s povrezhdeniem endotelial'noy vystilki pechenochnykh sinusoidov vsledstvie endotoksinemii i razvitiem endotelial'noy disfunktsii. Protsessy angiogeneza v pecheni takzhe tesno svyazany s funktsional'noy sostoyatel'nost'yu endoteliya. Odnako mekhanizmy i rol' endotelial'noy disfunktsii v patogeneze razvitiya gepatita i progressirovaniya ego v tsirroz pecheni malo izucheny. Aktual'nym takzhe yavdyaetsya razrabotka i vnedrenie v klinicheskuyu praktiku adekvatnykh metodov otsenki funktsional'nogo sostoyaniya endoteliya i sposobov korrektsii endotelial'nykh narusheniy. Dannaya kniga prednaznachena dlya vrachey obshchey praktiki, terapevtov, infektsionistov, gastroenterologov, vrachey klinicheskoy laboratornoy diagnostiki i nauchnykh rabotnikov.