New ideas and methods are needed to kill cancer cells selectively.In the last 40 years, using virus to treat different cancers seemed interesting; however, due to multiple genes involved to progress and metastasize cancer cells we are still looking to find a gene as a main target if we believe cancer is a genetic disease. The main question is: How oncolytic viruses can disrupt and escape from the tumour mass after intratumoral injection? It is not easy to determine that the next new findings and therapies might come from. In my opinion, this is very important to keep in mind, each live cell is trying to go to the next generation and our challenge with cancer cells just started.