Cancer is one of the deadliest diseases in this society. To overcome this problem, we studied different types of Epigenetic targets which are the root cause for Cancer. Epigenetics is the study of heritable changes in gene regulation that do not involve a change in the DNA sequence or the sequence of the proteins associated with DNA. In our study we have taken the targets as Histone Demethylase and Histone Deacetylase, total of 178 molecules were taken and were screened according to Lipinski Rule of five. Commercial available drugs were taken into consideration for the comparative study. In target Histone Demethylase, the final screened molecules were Galangin, Splitomicin, Salinosporamide A, Curcumin, Genistein. In Histone Deacetylase the final screened molecules were Salinosporamide A, Genistein and Caffeic Acid In both the targets final screened molecules were subjected to IC 50 calculation and, ADME TOX analysis. All the screened molecules show the less mutagenecity when compared to the Commercial Available drugs. Hence we conclude that these are the 7 molecules which act against the Epigenetic related cancer.